Answers are grounded in this paper and cite their sources.
A new method constructs C2-spiropseudoindoxyls from 2-nitrobenzaldehydes and sulfonyl hydrazones, indicating a pathway for bioactive modifications.
A metal- and oxidant-free protocol for the construction of diverse C2-spiropseudoindoxyl derivatives from 2-nitrobenzaldehydes and readily prepared sulfonyl hydrazones has been developed. Mechanistic studies suggest an intramolecular addition/SNAr/1,5-H shift sequence. This strategy delivers valuable C2-spiro-piperidine and -azetidine indolin-3-one scaffolds for bioactive molecule modification.
No takes yet. Share an insight, caveat, or question.
Chen et al. (2026) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: