Photodynamic therapy and anti-vascular endothelial growth factor for acute central serous chorioretinopathy: an updated systematic review and meta-analysis

March 1, 2026Survey of OphthalmologyOpen Access

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Key Points

Evaluate the effectiveness of photodynamic therapy compared to anti-VEGF agents for acute central serous chorioretinopathy.
Conducted a PRISMA-compliant meta-analysis of comparative studies
Searched PubMed, EMBASE, and CENTRAL databases for studies from October 2014 to May 2025
Included 11 studies (5 randomized and 6 non-randomized) involving 464 eyes
Photodynamic therapy showed significant improvement in best-corrected visual acuity and central macular thickness at multiple follow-up points
PDT-treated eyes were nearly 4 times more likely to achieve complete fluid resolution at one month
Anti-VEGF therapy resulted in only temporary anatomical improvements without significant visual benefits

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Meta-analysis evaluates photodynamic therapy's benefits in acute central serous chorioretinopathy, suggesting effective visual recovery.

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Algodi et al. (2026) studied this question.

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