Prognostic Value of N-terminal pro-B-type Natriuretic Peptide for Risk Stratification in Adults with Fontan Palliation

Q: What does this research mean for the field?

Serial NT-proBNP levels are significantly associated with death or transplant in adults with Fontan palliation, outperforming single NT-proBNP measurements and traditional imaging or hemodynamic indices for prognostic risk stratification. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Omar Abozied; William R. Miranda; Yogesh V.N. Reddy; Zeyad Kholeif; Heidi M. Connolly; Allan S. Jaffe; Alexander C. Egbe

doi:10.1016/j.cjcpc.2026.03.001

March 1, 2026CJC Pediatric and Congenital Heart DiseaseOpen Access

Prognostic Value of N-terminal pro-B-type Natriuretic Peptide for Risk Stratification in Adults with Fontan Palliation

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Key result

Serial NT-proBNP levels outperform single measurements in predicting death or transplant in adults with Fontan palliation.

Why the study?

Data were limited regarding the prognostic role of NT-proBNP in adults with Fontan palliation.

Does serial NT-proBNP measurement predict death or transplant in adults with Fontan palliation?

Structured PICO

Does serial NT-proBNP measurement predict death or transplant in adults with Fontan palliation?

P

Population

369 adults with Fontan palliation, age 278 years (as written in text), 55% male, with at least 1 NT-proBNP measurement in the outpatient clinic between 2003-2023.

I

Intervention

Serial NT-proBNP measurements (calculated as the mean of the first 3 measurements)

O

Outcome

Death or transplanthard clinical

Serial NT-proBNP measurements provide superior prognostic value for predicting death or transplant in adults with Fontan palliation compared to single baseline measurements or standard imaging and hemodynamic indices.

Implication

Serial NT-proBNP monitoring may refine risk stratification in adult Fontan patients; extends prognostic value beyond single measurements and standard indices.

Discussion

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Cite This Study

Abozied et al. (2026) studied this question. Serial NT-proBNP levels were significantly associated with death/transplant in adults with Fontan palliation, outperforming single NT-proBNP measurements.

synapsesocial.com/papers/69b79df38166e15b153ab1ba https://doi.org/10.1016/j.cjcpc.2026.03.001

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Prognostic Value of N-terminal pro-B-type Natriuretic Peptide for Risk Stratification in Adults with Fontan Palliation

Structured PICO

Implication

Discussion

Cite This Study

Prognostic Value of N-terminal pro-B-type Natriuretic Peptide for Risk Stratification in Adults with Fontan Palliation

Structured PICO

Implication

Discussion

Cite This Study

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