What question did this study set out to answer?

The study aims to compare the relative strength of associations between urinary albumin-to-creatinine ratio (uACR) and protein-to-creatinine ratio (uPCR) with kidney outcomes in pediatric chronic kidney disease (CKD).

March 16, 2026Nephrology Dialysis Transplantation

Urinary Albumin-to-Creatinine Associates More Closely than Protein-to-Creatinine Ratio with Kidney Outcomes in Pediatric Chronic Kidney Disease

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The study aims to compare the relative strength of associations between urinary albumin-to-creatinine ratio (uACR) and protein-to-creatinine ratio (uPCR) with kidney outcomes in pediatric chronic kidney disease (CKD).
Analyzed data from 596 children aged 6–17 years with CKD stages 3–4.
Evaluated baseline uACR and uPCR using log-transformation and z-standardization.
Assessed CKD progression through annual eGFR slope and composite kidney outcomes.
Utilized adjusted linear mixed-effect and Cox models for association estimation.
A 1-SD increase in log-uACR is linked to a 2.17-fold higher risk of adverse kidney outcomes.
A 1-SD increase in log-uPCR is associated with a 1.70-fold higher risk.
uACR demonstrated a 28% stronger association compared to uPCR, highlighting its significance in risk stratification.

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Implication

Head-to-head evaluation highlights the superior association of uACR with kidney outcomes in children with CKD, suggesting a need for focused monitoring.

Cite This Study

Murunga et al. (2026) studied this question.

synapsesocial.com/papers/69b79e538166e15b153ab87e https://doi.org/10.1093/ndt/gfag061

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Implication

Head-to-head evaluation highlights the superior association of uACR with kidney outcomes in children with CKD, suggesting a need for focused monitoring.

Urinary Albumin-to-Creatinine Associates More Closely than Protein-to-Creatinine Ratio with Kidney Outcomes in Pediatric Chronic Kidney Disease

Key Points

Discussion

Implication

Cite This Study

Urinary Albumin-to-Creatinine Associates More Closely than Protein-to-Creatinine Ratio with Kidney Outcomes in Pediatric Chronic Kidney Disease

Key Points

Discussion

Implication

Cite This Study

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