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The study investigates the potential of Cissus quadrangularis ethanolic extract as an anti-stress agent in vivo.

In silico and animal model study of Cissus quadrangularis stem ethanolic extract for unpredictable spontaneous stress

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The study investigates the potential of Cissus quadrangularis ethanolic extract as an anti-stress agent in vivo.
Conducted molecular docking and ADMET studies to analyze phytoconstituents.
Evaluated acute oral toxicity to establish safety of extract up to 700 mg/kg.
Assessed oxidative stress indicators GSH, SOD, CAT, MDA, and MPO in unpredictable spontaneous stress models.
Performed histopathological examination of tissue samples after treatment with extracts at various dosages.
Found significant increases in MDA and MPO levels in USS compared to control.
Demonstrated that both 300 and 500 mg/kg doses of the extract significantly reduced MDA levels.
Histopathological studies indicated positive outcomes from treatments at 300 and 500 mg/kg, suggesting tissue protection.

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Examines the anti-stress effects of Cissus quadrangularis extract in animal models, suggesting its potential therapeutic application.

Syed et al. (2026) studied this question.

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