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Research shows safety when discontinuing antiseizure medication in neonates after seizures resolve, suggesting new guidelines for treatment.
Prolonged administration of ASM for several months after resolution of acute provoked neonatal seizures may expose infants to unnecessary medications. These results provide additional evidence for safety of discontinuing ASM for most neonates soon after the resolution of acute provoked seizures-a practice that is recommended in the International League Against Epilepsy (ILAE) guideline for neonatal seizure management.
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Glass et al. (2026) studied this question.
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