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March 17, 2026The Brazilian Journal of Infectious DiseasesOpen Access

Bicuspid Aortic Valve: A Silent Danger

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Why the study?

Bicuspid aortic valve carries a risk of complications, including infective endocarditis, motivating a description of clinical characteristics of patients with infective endocarditis on bicuspid aortic valve.

Population

35 patients with infective endocarditis on bicuspid aortic valve out of 578 adult infective endocarditis cases

Design

Prospective observational cohort study with post hoc analysis

Authors

JRJúlia Cataldo Mendes RodriguesNFNícolas de Albuquerque Pereira FeijóoFBFernanda Loyola de Barros

Discussion

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Overview

Supports early surgery in BAV IE; extends evidence of high mortality despite intervention in young men.

Key Points

  • The study aims to characterize patients with infective endocarditis related to bicuspid aortic valve and highlight associated risks.
  • Conducted a prospective observational cohort study in a cardiac surgery center.
  • Included adults hospitalized with infective endocarditis between 2006 and 2025.
  • Analyzed clinical data of patients with infective endocarditis associated with bicuspid aortic valve.
  • Identified infective endocarditis in 6% of cases, predominantly in men with a mean age of 39.1.
  • Aortic regurgitation and vegetations were found in 68.6% of cases.
  • 65.7% experienced acute heart failure, indicating severe complications.

Structured PICO

P
Population
35 adult patients hospitalized with infective endocarditis on a bicuspid aortic valve (IE-BAV) out of 578 total IE cases, mean age 39.1 years, 85.7% male.
O
Outcome
Clinical characteristics, complications, and outcomes of infective endocarditis on bicuspid aortic valve

Infective endocarditis on bicuspid aortic valves predominantly affects young men, is often of oral origin, and carries a high rate of surgical indication and mortality despite intervention.

Cite This Study

Rodrigues et al. (2026) studied this question.

synapsesocial.com/papers/69b8ef36deb47d591b8c53c4https://doi.org/10.1016/j.bjid.2026.105092
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