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March 17, 2026The Brazilian Journal of Infectious DiseasesOpen Access

False-Negative Serum Cryptococcal Antigen (Lf-Crag) Due to Post-Zone Effect in a Person Living With Hiv With Severe Disseminated Cryptococcal Disease and Probable Coinfection With H. Capsulatum

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Authors

VCVitor José da Silva ClassmannGSGenildo Farias da SilvaGRGabriel Fernando Elias dos Reis

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Overview

A case reports on false-negative serum antigen in HIV severe cryptococcal disease, suggesting diagnostic strategies.

Key Points

  • The study aims to address the significance of false-negative serum LF-CrAg results and potential coinfection in severe cryptococcal disease.
  • Case report of a 26-year-old man with HIV and disseminated cryptococcal disease
  • Assessment of serum LF-CrAg and fungal cultures after introduction of antiretroviral therapy
  • Diagnostic tests included lumbar puncture, cultures, histopathology, and serology for H. capsulatum
  • Initial serum LF-CrAg was negative but became reactive after dilution, confirming a post-zone effect
  • Cultures confirmed Cryptococcus neoformans infection sensitive to treatment
  • Coinfection with H. capsulatum was suggested based on serology results

Cite This Study

Classmann et al. (2026) studied this question.

synapsesocial.com/papers/69b8ef6ddeb47d591b8c5838https://doi.org/10.1016/j.bjid.2026.105259
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1When the Test Lies: Fatal Cryptococcosis and the Prozone Effect in Advanced HIV Infection2026
  2. 2B72-21 Cryptococcal Pneumonia in an Immunocompetent Adult Patient: A Case Marked by Diagnostic and Therapeutic Challenges2026
  3. 3A Case of Disseminated Cryptococcus in an HIV-Positive Patient2024
  4. 4B72-20 Mediastinal Lymphadenopathy Due to Disseminated Cryptococcus in a Patient With Newly Diagnosed HIV/AIDS2026
  5. 5Disseminated Cryptococcosis in a Non-HIV Patient: Diagnostic Value of Integrating mNGS, Culture, and Antigen Testing2026