What is the clinical evidence from this study?

Population: Infectious bronchitis virus (IBV) (n=90). Intervention: vGA08 and Mass type IBV vaccines vs. Non-vaccinated. Primary outcome: Amount of challenge virus detected at 5 days post-challenge (1 to 3-log reduction, p=<0.05).

What question did this study set out to answer?

To evaluate the efficacy of two vaccines, vGA08 and Mass type, against multiple IBV antigenic variants in poultry.

March 17, 2026Veterinary ResearchOpen Access

Cross-protection studies using vGA08 and Mass type IBV vaccines against four different antigenic variant viruses currently circulating in poultry in the USA and Canada

Q: What are the key findings of this study?

Simultaneous vaccination with vGA08 and Mass vaccines significantly reduced clinical signs and decreased challenge virus load by 1 to 3 logs against four circulating IBV variants compared to no vaccination.

Q: What question did this study set out to answer?

To evaluate the efficacy of two vaccines, vGA08 and Mass type, against multiple IBV antigenic variants in poultry.

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Key result

Simultaneous vGA08 and Mass vaccination reduces clinical signs and cuts IBV viral load by ~3 logs.

1 to 3-log reduction
P<0.05
n=90

Why the study?

Due to circulating antigenic IBV variants and limited homologous vaccines, the study evaluated whether simultaneous vGA08 and Mass type vaccination protects chickens against four circulating variant strains.

Does simultaneous vaccination with vGA08 and Mass type IBV vaccines reduce clinical signs and viral load in chickens challenged with circulating variant IBV strains?

Key Points

To evaluate the efficacy of two vaccines, vGA08 and Mass type, against multiple IBV antigenic variants in poultry.
Administered vGA08 and Mass type vaccines simultaneously to chicks at one day old.
Challenged vaccinated and non-vaccinated birds with four different IBV variant strains at four weeks old.
Assessed clinical signs and virus levels in both groups post-challenge.
Vaccinated birds showed reduced clinical signs compared to non-vaccinated ones.
The level of challenge virus detected was significantly lower in vaccinated birds across all variants.
Findings suggest effective cross-protection provided by the tested vaccines against current IBV strains.

Structured PICO

Does simultaneous vaccination with vGA08 and Mass type IBV vaccines reduce clinical signs and viral load in chickens challenged with circulating variant IBV strains?

Population

90 specific pathogen free (SPF) chickens

Intervention

Simultaneous vaccination with vGA08 and Mass type IBV vaccines by eye-drop at 1 day of age, followed by challenge with 4 different IBV variant strains (PA/1220/98, CA/1737/04, NC/DARK/23, and Canada/DMV1639/23) at 28 days post-vaccination

Comparator

Non-vaccinated chickens challenged with the same variant strains (positive controls) and non-vaccinated, non-challenged chickens (negative controls)

Outcome

Clinical signs (respiratory scores) and challenge virus detection (viral genome copies/ml) in choanal swabs at 5 days post-challengesurrogate

Main Result

Effect estimate: 1 to 3-log reduction

p-value: p=<0.05

Limitations

Heterologous cross-protection does not guarantee complete immunity.
Birds can still become infected with the heterologous field virus and can exhibit mild clinical signs.
The exact mechanism underlying cross-protection remains unclear.

Discussion

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Implication

Supports simultaneous vGA08 and Mass type IBV vaccination in poultry flocks; extends cross-protection to four circulating variant strains.

Cite This Study

Jackwood et al. (2026) studied Infectious bronchitis virus (IBV) (n=90). vGA08 and Mass type IBV vaccines vs. Non-vaccinated was evaluated on Amount of challenge virus detected at 5 days post-challenge (1 to 3-log reduction, p=<0.05). Simultaneous vaccination with vGA08 and Mass vaccines significantly reduced clinical signs and decreased challenge virus load by 1 to 3 logs against four circulating IBV variants compared to no vaccination.

synapsesocial.com/papers/69b8f0fddeb47d591b8c5bf6 https://doi.org/10.1186/s13567-026-01718-w

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Implication

Supports simultaneous vGA08 and Mass type IBV vaccination in poultry flocks; extends cross-protection to four circulating variant strains.

Cross-protection studies using vGA08 and Mass type IBV vaccines against four different antigenic variant viruses currently circulating in poultry in the USA and Canada

Key Points

Structured PICO

Main Result

Limitations

Discussion

Implication

Cite This Study

Cross-protection studies using vGA08 and Mass type IBV vaccines against four different antigenic variant viruses currently circulating in poultry in the USA and Canada

Key Points

Structured PICO

Main Result

Limitations

Discussion

Implication

Cite This Study

Also Consider

Also Consider