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January 1, 2026Journal of Oral ScienceOpen Access

Ex-vivo evaluation of intratubular antibacterial activity and biocompatibility of two hydraulic calcium silicate-based endodontic sealers

Carlo Gaeta Federica Veneri Giulia Malvicini Jessika Bertacchini Francesco Cavani Omar Shanableh Eva Tollapi Chiara Falciani Simone Grandini Luigi Generali

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Key Points

To evaluate the antibacterial activity and biocompatibility of two hydraulic calcium silicate-based endodontic sealers.
Ex-vivo assessments were conducted on two types of sealers.
Antibacterial activity was tested against specific bacterial strains.
Biocompatibility was evaluated using standard assays.
Both sealers demonstrated similar levels of antibacterial effectiveness.
Bacterial viability was found to be greater in the coronal region.

Implication

Ex-vivo evaluation shows similar antibacterial activity in endodontic sealers, indicating effective treatment options.

Abstract

Both sealers demonstrated similar antibacterial effectiveness and biocompatibility, with greater bacterial viability in the coronal region.

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Cite This Study

Gaeta et al. (2026) studied this question.

synapsesocial.com/papers/69ba41e04e9516ffd37a1df4 https://doi.org/10.2334/josnusd.25-0024

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Antimicrobial efficacy of calcium silicate-based bioceramic sealers against Enterococcus faecalis and Staphylococcus aureus – An in vitro study2024 · 13 citations
2Evaluation of the Cytotoxic Effect of Calcium Silicate-Based Bioceramic Sealers: An In Vitro Comparative StudyIn Vitro Study · 2026
3Comparative in vitro analysis of the antifungal activity of different calcium silicate-based endodontic sealers2024
4Antibiofilm Efficacy of Calcium Silicate-Based Endodontic Sealers2024 · 6 citations
5In Vitro Bioactivity and Cytotoxicity Assessment of Two Root Canal Sealers2025 · 9 citations

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