Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
March 18, 2026Biochemical PharmacologyOpen Access

Topical and systemic skin aging interventions: Evidence, pitfalls and perspectives

View Full Paper
Ask AI
Bookmark
Share

Authors

AGA. GürtlerJSJonathan P. SiroisIHIndra J. Heckenbach

Discussion

Loading...

Member takes

Overview

This review assesses skin aging interventions and their effectiveness, highlighting gaps in clinical evidence.

Key Points

  • To critically evaluate existing interventions for skin aging and their clinical effectiveness.
  • Reviewed various topical and systemic skin aging interventions.
  • Assessed the physicochemical properties and formulation stability of active ingredients.
  • Analyzed clinical evidence for effectiveness and absorption of interventions.
  • Retinoids are supported as the most effective intervention, though tolerability issues exist.
  • Efficacy of antioxidants, hormonal therapies, hydrators, and collagen peptides remains unclear.
  • Many studies have methodological limitations, affecting the reliability of outcomes.

Cite This Study

Gürtler et al. (2026) studied this question.

synapsesocial.com/papers/69ba420a4e9516ffd37a1e22https://doi.org/10.1016/j.bcp.2026.117898
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Top weapons in skin aging and actives to target the consequences of skin cell senescence2024 · 39 citations
  2. 2Research progress on mechanisms of skin aging and anti-aging strategies2026
  3. 3Advances in skin aging: integrating epigenetic, cellular, and immune mechanisms for targeted therapy2026
  4. 4Integrative approaches to aging: Mechanisms, antiaging strategies, and emerging biomedical interventions2026
  5. 5Comprehensive Management of Premature Skin Aging: Current Strategies, Treatments, and Emerging Therapies2024