Key result
Discontinuing HRT is linked to high symptom recurrence and potentially higher cardiovascular and dementia risks.
Why the study?
HRT prescribing has increased significantly with attention largely on initiation and ongoing prescribing, but little focus has been given to therapy discontinuation.
What are the implications of discontinuing hormone replacement therapy regarding safety, symptom recurrence, and cardiovascular or dementia risks?
What are the implications of discontinuing hormone replacement therapy regarding safety, symptom recurrence, and cardiovascular or dementia risks?
Discontinuation of hormone replacement therapy requires careful consideration due to risks of symptom recurrence and potential increases in age-related cardiovascular disease and dementia.
Requires careful counseling before HRT discontinuation; hypothesis-generating and warrants trials on long-term CV and dementia safety.
Hormone replacement therapy (HRT) prescribing in England has increased significantly in recent years, with attention largely directed towards initiation and ongoing prescribing. However, little focus has been given to the discontinuation of therapy. This article explores the implications of HRT discontinuation in relation to safety and prescribing practice, including high rates of symptom recurrence and re-initiation of treatment, as well as the potential for increased risks of age-related cardiovascular disease and dementia.
No takes yet. Share an insight, caveat, or question.
Hasan H Alsararatee (2026) studied this question. Discontinuation of hormone replacement therapy is associated with high rates of symptom recurrence and potentially increased risks of age-related cardiovascular disease and dementia.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: