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March 18, 2026ACS Infectious Diseases

N -(ω-Guanidinoalkyl)amides of Eremomycin: New Type of Glycopeptides with High Potency against Planktonic Forms and Biofilms of Resistant Bacteria

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Authors

EMElena I. MoiseenkoGause Institute of New Antibiotics Russian Academy of Medical SciencesLLLyudmila N. LysenkovaGause Institute of New Antibiotics Russian Academy of Medical SciencesAGAlexander S. GostevGause Institute of New Antibiotics Russian Academy of Medical Sciences

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Implication

Novel glycopeptide antibiotics show strong efficacy against resistant bacteria and biofilms, indicating potential for overcoming current treatment challenges.

Key Points

  • The research aims to develop novel eremomycin derivatives to combat multidrug-resistant bacteria and biofilm infections.
  • Synthesis of guanidine-containing eremomycin derivatives.
  • In vitro testing against vancomycin-sensitive and -resistant bacteria.
  • Evaluation of bactericidal activity in biofilms.
  • Physicochemical characterization using 2D NMR and mass spectrometry.
  • In vivo assessment in a murine sepsis model.
  • Compound 12a showed higher potency against resistant strains compared to vancomycin.
  • Demonstrated sustained bactericidal activity in biofilms without promoting biofilm formation.
  • In vivo tests indicated an ED50 value 14 times lower than that of vancomycin.

Cite This Study

Moiseenko et al. (2026) studied this question.

synapsesocial.com/papers/69ba43cb4e9516ffd37a5545https://doi.org/10.1021/acsinfecdis.5c01004
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