What question did this study set out to answer?

To investigate the relationship between nasopharyngeal microbiome composition and the development of post-acute sequelae of SARS-CoV-2 (PASC) in COVID-19 patients.

March 19, 2026Microbiology SpectrumOpen Access

Association of nasopharyngeal Dolosigranulum pigrum and Corynebacterium species with post-acute sequelae of SARS-CoV-2 in a longitudinal cohort

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Authors

BWBradley WardPharmacoGenetics (China)LBLaure B. Bindelsde Duve Institute JBJean-Luc BalligandCliniques Universitaires Saint-Luc

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Implication

Longitudinal study examines nasopharyngeal microbiome's relation to COVID-19 outcomes, suggesting implications for long-COVID.

Key Points

To investigate the relationship between nasopharyngeal microbiome composition and the development of post-acute sequelae of SARS-CoV-2 (PASC) in COVID-19 patients.
Longitudinal cohort design with samples from healthy individuals and COVID-19 patients.
Microbiota composition assessed using metagenomic shotgun sequencing.
Alpha and beta diversity analyses performed to evaluate community diversity between groups.
Differential abundance testing conducted to identify specific species linked to PASC.
No significant differences were found in overall microbiome diversity across groups.
Dolosigranulum pigrum and Corynebacterium species correlated with PASC development.
Lower levels of protective taxa associated with antibiotic use linked to higher PASC risk.

Cite This Study

Ward et al. (2026) studied this question.

synapsesocial.com/papers/69bb9300496e729e62980c98 https://doi.org/10.1128/spectrum.02313-25

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Association of nasopharyngeal Dolosigranulum pigrum and Corynebacterium species with post-acute sequelae of SARS-CoV-2 in a longitudinal cohort

Discussion

Member takes

Implication

Key Points

Cite This Study

Association of nasopharyngeal Dolosigranulum pigrum and Corynebacterium species with post-acute sequelae of SARS-CoV-2 in a longitudinal cohort

Discussion

Member takes

Implication

Key Points

Cite This Study

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