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March 19, 2026SLEEP AdvancesOpen Access

Exploratory Associations of Sleep Spindles and Sleep Disordered Breathing Indices with Hippocampal and Thalamic Volume, and Cortical Thickness, and Cerebrovascular Biomarkers Among Community Dwelling Older Adults: Results from the Brain in Motion

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Authors

ADAlison DonaldUniversity of CalgaryABAndrew E. BeaudinUniversity of CalgaryMPMatiram PunUniversity of Calgary

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Implication

Exploratory study examines brain structure and sleep associations in community-dwelling older adults, indicating potential links.

Key Points

  • This study aims to explore the relationships between sleep disordered breathing, sleep spindles, and brain structure in older adults.
  • Seventy-one community-dwelling older adults underwent magnetic resonance imaging and polysomnography.
  • Investigated associations between sleep disordered breathing indices and brain structure.
  • Examined the links between brain volume metrics and sleep spindle characteristics.
  • No significant relationships were found between obstructive sleep apnea indices and cerebral blood flow or white matter hyperintensities.
  • Spindle frequency showed a weak association with thalamic volume; however, this did not remain significant after corrections.
  • Hippocampal volume and cortical thickness were not related to sleep spindles.

Cite This Study

Donald et al. (2026) studied this question.

synapsesocial.com/papers/69bb9300496e729e62980d62https://doi.org/10.1093/sleepadvances/zpag028
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