Organocatalytic approach to vinylic nucleophilic substitution at electrophilic alkenes

Matvey K. Ilyushchenko; Rinat F. Salikov; Yury Tomilov

doi:10.1039/d6qo00037a

January 1, 2026Organic Chemistry Frontiers

Organocatalytic approach to vinylic nucleophilic substitution at electrophilic alkenes

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Key Points

The study aims to explore the potential of nucleophilic catalysis for vinylic substitution reactions at sp²-carbon centers.
Utilized organocatalysts to facilitate nucleophilic substitutions.
Analyzed the reaction conditions and mechanisms for electrophilic alkenes.
Compared the efficiency of various nucleophiles and catalysts.
Demonstrated successful vinylic substitutions using specific nucleophiles.
Highlighted novel pathways for activating electrophilic alkenes.
Increased reaction efficiency compared to traditional methods.

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Implication

Nucleophilic catalysis demonstrates effective vinylic substitution at electrophilic alkenes, indicating broader applications.

Abstract

Nucleophilic catalysis is a powerful and well-developed tool for activating and manipulating carbon-centered electrophiles. However, its application to substitution at sp²-carbon atoms has been explored only for acylation reactions and,...

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Cite This Study

Ilyushchenko et al. (2026) studied this question.

synapsesocial.com/papers/69bb9357496e729e62981742 https://doi.org/10.1039/d6qo00037a

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Organocatalytic approach to vinylic nucleophilic substitution at electrophilic alkenes

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Organocatalytic approach to vinylic nucleophilic substitution at electrophilic alkenes

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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