Why the study?
Is genetic variation in non-sarcomeric genes associated with hypertrophic cardiomyopathy?
Population
Patients with hypertrophic cardiomyopathy (HCM)
Design
Other
Authors
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Challenges prior non-sarcomeric gene lists in HCM panels; leaves open need for validation before revising testing or guidelines.
Is genetic variation in non-sarcomeric genes associated with hypertrophic cardiomyopathy?
This study challenges the role of most non-sarcomeric genes previously implicated in HCM, reaffirming that sarcomeric genes are the primary known cause while highlighting that the etiology remains unknown for most patients.
Walsh et al. (2016) studied this question.
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