Associations of TNFRSF10A with Central Serous Chorioretinopathy, Polypoidal Choroidal Vasculopathy and Age-related Macular Degeneration

March 1, 2026Ophthalmology ScienceOpen Access

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Key Points

The study investigates how TNFRSF10A genetic variants are associated with cCSCR, PCV, and nAMD.
Conducted a case-control study with 1,478 Chinese participants.
Genotyped 13 SNPs in the TNFRSF10A gene, focusing on promoter and coding regions.
Employed logistic regression to evaluate allelic and haplotype associations adjusted for age and sex.
Performed conditional analyses to assess independent effects.
For cCSCR without MNV, four SNPs were significantly associated, with odds ratios ranging from 1.65 to 1.91.
The reference SNP, rs13278062, also showed a significant association (OR = 1.81).
For PCV, a single SNP, rs36005462, showed a marginal association (OR = 0.58).
No significant associations were found for nAMD or cCSCR with MNV.

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Case-control genetic association study finds links between TNFRSF10A variants and specific eye diseases, implying different genetic influences.

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Chen et al. (2026) studied this question.

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