Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
March 21, 2026Nature CommunicationsOpen Access

IL-17RA signaling promotes the dedifferentiation of Paneth progenitors through ADAM17 to regenerate gut epithelium post-irradiation

View Full Paper
Ask AI
Bookmark
Share

Authors

CKCody KempenASAnkita SinghKBKeith A. Breau

Discussion

Loading...

Member takes

Overview

Experimental analysis reveals IL-17RA signaling aids Paneth cell regeneration in intestinal tissues post-injury, implying a new therapeutic target.

Key Points

  • To explore the role of IL-17RA signaling in Paneth cells for tissue regeneration after intestinal injury.
  • Utilized Paneth cell-specific IL-17RA knockout mice.
  • Conducted anti-IL-17A neutralizing studies.
  • Employed lineage tracer mice to track cellular changes.
  • Assessed the effects of ADAM17 overexpression in mutant mice.
  • IL-17RA signaling is essential for Paneth cells to acquire stem-like properties.
  • Reduced ADAM17 expression linked to regeneration defects in specific knockout mice.
  • Overexpressing ADAM17 rescues regeneration issues in IL-17RA knockout mice.
  • IL-17A enhances Nox1 expression, leading to increased ADAM17 activity.

Cite This Study

Kempen et al. (2026) studied this question.

synapsesocial.com/papers/69be34d16e48c4981c673045https://doi.org/10.1038/s41467-026-70479-z
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Pancreatic Epithelial IL17/IL17RA Signaling Drives B7-H4 Expression to Promote Tumorigenesis2024 · 3 citations
  2. 2When gut stem cells talk to the immune system: impacts on remote tumor 22404422026
  3. 3PANETH CELLS ALPHA DEFENSINS- PATHOGENETIC TARGET OF ADOPTIVE T CELL TRANSFER IBD MODEL2026
  4. 4IL-17RA–Mediated Epithelial Cell Activity Prevents Severe Inflammatory Response to <i>Helicobacter pylori</i> Infection2024 · 1 citations
  5. 5Data from Pancreatic Epithelial IL17/IL17RA Signaling Drives B7-H4 Expression to Promote Tumorigenesis2024