PIEZO1 regulates smooth muscle cell plasticity by integrating mechanical stretch with glycolytic metabolism

Q: What does this research mean for the field?

PIEZO1-mediated mechano-metabolic coupling regulates pulmonary arterial smooth muscle cell plasticity by integrating mechanical stretch with cellular glycolysis during pulmonary vascular remodeling. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Yapeng Cao; Liran Xu; Meng Zhang; Ailing Su; Siyu Wang; Ting Li; Siyu Liu; Ziyang Mao; Yu He; Zehua Shao; Jiamin Zhang; Youhua Wang; Huijing Tian; Yue Sun; Yongxin Li; Luqin Yan; G F Zhang; Shiquan Sun; Na Mei; Fangyuan Chen; Ying Xiong; Guozheng Liang; Stefan Offermanns; Yang Yan; Z Yuan; Shengpeng Wang

doi:10.1093/cvr/cvag058

Key Points

The aim was to investigate how PIEZO1 influences smooth muscle cell plasticity through its interaction with glycolytic metabolism under mechanical stretch.
Examined the role of PIEZO1 in pulmonary arterial smooth muscle cells (PASMCs) under mechanical stretch.
Analyzed cellular glycolysis in relation to PIEZO1 activity.
Utilized experimental models to study mechano-metabolic interactions during vascular remodeling.
Identified PIEZO1 as a key regulator of smooth muscle cell plasticity.
Demonstrated that mechanical stretch enhances glycolytic activity via PIEZO1 signaling.
Revealed a novel mechanism linking mechanical and metabolic processes in vascular remodeling.

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Implication

Demonstrates that PIEZO1 integrates mechanical stretch with glycolysis in smooth muscle cells, suggesting a role in pulmonary vascular health.

Abstract

Our study reveals that PIEZO1-mediated mechano-metabolic coupling contributes to PASMCs plasticity. This discovery identified an intrinsic mechanism that integrates mechanical stretch with cellular glycolysis during pulmonary vascular remodeling.

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Cite This Study

Cao et al. (2026) studied this question.

synapsesocial.com/papers/69be354a6e48c4981c673631 https://doi.org/10.1093/cvr/cvag058

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PIEZO1 regulates smooth muscle cell plasticity by integrating mechanical stretch with glycolytic metabolism

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Cite This Study

PIEZO1 regulates smooth muscle cell plasticity by integrating mechanical stretch with glycolytic metabolism

Key Points

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Implication

Abstract

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Cite This Study

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