PIEZO1 regulates smooth muscle cell plasticity by integrating mechanical stretch with glycolytic metabolism

Key Points

• The aim was to investigate how PIEZO1 influences smooth muscle cell plasticity through its interaction with glycolytic metabolism under mechanical stretch.
• Examined the role of PIEZO1 in pulmonary arterial smooth muscle cells (PASMCs) under mechanical stretch.
• Analyzed cellular glycolysis in relation to PIEZO1 activity.
• Utilized experimental models to study mechano-metabolic interactions during vascular remodeling.
• Identified PIEZO1 as a key regulator of smooth muscle cell plasticity.
• Demonstrated that mechanical stretch enhances glycolytic activity via PIEZO1 signaling.
• Revealed a novel mechanism linking mechanical and metabolic processes in vascular remodeling.