Key result
Modular AVEIR AR upgrade restores ~98% AV synchrony and resolves hypotensive symptoms.
Why the study?
Real-world experience with sequential upgrade from an AVEIR VR to a dual-chamber AVEIR DR leadless pacing system remains limited.
Does a staged modular upgrade with an AVEIR AR leadless atrial device restore AV synchrony and resolve symptoms in a patient with an existing AVEIR VR ventricular device and evolving conduction disease?
Case Report (n=1)
No
Does a staged modular upgrade with an AVEIR AR leadless atrial device restore AV synchrony and resolve symptoms in a patient with an existing AVEIR VR ventricular device and evolving conduction disease?
A staged modular upgrade from a single-chamber ventricular leadless pacemaker to a dual-chamber system is feasible, safe, and effective for restoring AV synchrony in a patient with progressive conduction disease.
May support staged modular leadless upgrade in select patients with progressive conduction disease; leaves open confirmation in prospective studies.
Leadless pacing systems have evolved toward modular configurations that enable staged restoration of atrioventricular (AV) synchrony without transvenous leads. Real-world experience with a sequential upgrade from AVEIR VR to a dual-chamber AVEIR DR system remains limited. We report a case of staged modular leadless upgrade performed in a patient with progressive sinus node dysfunction, intermittent high-grade AV block, and symptomatic loss of AV synchrony following prior ventricular leadless pacing. A 74-year-old man with a history of mitral valve repair and atrial flutter ablation initially received an AVEIR VR ventricular device. One year later, he developed sinus pauses and hemodynamic symptoms related to AV dyssynchrony. Because the patient declined transvenous pacing, an atrial AVEIR AR module was implanted to establish dual-chamber pacing within a fully leadless system. The procedure was uncomplicated and resulted in restoration of AV synchrony and clinical improvement at follow-up. This report demonstrates the feasibility of staged modular upgrades within a leadless pacing platform in selected patients with evolving conduction disease.
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Abdrakhmanov et al. (2026) conducted a case report in Sinus node dysfunction and symptomatic loss of AV synchrony (n=1). AVEIR AR module for staged modular upgrade to AVEIR DR was evaluated on Restoration of AV synchrony and clinical improvement. Staged modular upgrade with an atrial AVEIR AR device successfully restored >98% AV synchrony and completely resolved hypotensive symptoms without procedural complications.
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