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March 21, 2026Stem Cells InternationalOpen Access

The Enigmatic Teratoma: Tracing Tissue Origins Through Methylation Profiling

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Authors

WWWen-Chung WangCKChen-Yun KuoTHTai-Cheng Hou

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Overview

Analysis identifies methylation patterns in tumor suppressor genes of mature cystic teratomas, suggesting developmental insights.

Key Points

  • The aim is to understand the epigenomic changes in mature cystic teratomas to uncover their developmental origins.
  • Analyzed methylation statuses of 25 tumor suppressor genes
  • Used methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA)
  • Evaluated samples from 12 mature cystic teratomas of the ovary
  • Observed frequent methylation of GSTP1, RARB, ATM, CDKN2B, and KLLN in all samples
  • Noted high frequency of methylated APC and CD44 among samples
  • Identified varied frequencies of other genes such as CASP8, ESR1, and VHL

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/69be35ba6e48c4981c6741ebhttps://doi.org/10.1155/sci/1118933
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Amplifications of EVX2 and HOXD9-HOXD13 on 2q31 in mature cystic teratomas of the ovary identified by array comparative genomic hybridization may explain teratoma characteristics in chondrogenesis and osteogenesis2024
  2. 2Whole Exome Sequencing Reveals Potential Single Nucleotide Polymorphisms and Copy Number Variations in 26 Sporadic Patients with Immature Teratoma2026
  3. 3868 The role of DNA methylation profiling in malignant transformation of ovarian teratoma- two case reports2024
  4. 4Genomic profiling of meiotic errors and early malignant transformation events in ovarian mature teratoma2026
  5. 5Molecular characterization of growing teratoma syndrome in patients with testicular germ cell tumor.2024 · 1 citations