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March 21, 2026NatureOpen Access

Thymic health and immunotherapy outcomes in patients with cancer

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Authors

SBSimon BernatzVPVasco PrudenteSPS. P. Pai

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Overview

Demonstrates the connection between thymic health and improved immunotherapy responses in cancer, suggesting new strategies for treatment.

Key Points

  • To explore the relationship between thymic health and immunotherapy outcomes in cancer patients.
  • Analyzed thymic functionality using a deep-learning framework on CT images.
  • Included a pan-cancer cohort of 3,476 patients receiving immune checkpoint inhibitors.
  • Investigated associations between thymic health and clinical outcomes in various cancer types.
  • Higher thymic health correlated with reduced risks of cancer progression and mortality.
  • Associations remained significant across levels of PD-L1 and tumor mutation burden.
  • In the TRACERx study, thymic health linked to T cell receptor diversity and immune system pathways.

Cite This Study

Bernatz et al. (2026) studied this question.

synapsesocial.com/papers/69be36086e48c4981c6749f8https://doi.org/10.1038/s41586-026-10243-x
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