A Brønsted-based deep eutectic solvent as a green catalyst for the sustainable one-pot synthesis of 1,2,4,5-tetrasubstituted imidazole derivatives: in vitro cytotoxicity and in silico binding studies on HepG2 cells

Tuan-Anh Ngoc Tran; Linh Dieu Nguyen; Khoi Nam Nguyen; Phu Hoang Dang; Hai Truong Nguyen

doi:10.1039/d6ra00422a

January 1, 2026RSC AdvancesOpen Access

A Brønsted-based deep eutectic solvent as a green catalyst for the sustainable one-pot synthesis of 1,2,4,5-tetrasubstituted imidazole derivatives: in vitro cytotoxicity and in silico binding studies on HepG2 cells

View Full Paper

Ask AI

Bookmark

Share

Key Points

This research aims to develop a green catalyst for synthesizing tetrasubstituted imidazoles and assess their anticancer activity.
Synthesis of imidazoles through a one-pot reaction using [Bet]2[PTSA] as a green catalyst.
Structure-activity relationship analysis to evaluate the impact of substituents on anticancer properties.
In vitro cytotoxicity assays performed on HepG2 cells.
Tetrasubstituted imidazoles were successfully synthesized.
Phenolic hydroxyl and para-methoxy groups significantly enhanced anticancer activity.
Binding studies indicated favorable interactions with HepG2 cells.

Ask about this paper

Answers are grounded in this paper and cite their sources.

Implication

In vitro cytotoxicity and in silico binding studies reveal enhanced anticancer activity in imidazole derivatives.

Abstract

1,2,4,5-Tetrasubstituted imidazoles were synthesized via a green, one-pot reaction using [Bet] 2 [PTSA]. Structure-activity relationship analysis indicated that phenolic hydroxyl and para -methoxy substituents enhance anticancer activity.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Tran et al. (2026) studied this question.

synapsesocial.com/papers/69be362d6e48c4981c674dc2 https://doi.org/10.1039/d6ra00422a

View Full Paper

Ask AI

Bookmark

Share

A Brønsted-based deep eutectic solvent as a green catalyst for the sustainable one-pot synthesis of 1,2,4,5-tetrasubstituted imidazole derivatives: in vitro cytotoxicity and in silico binding studies on HepG2 cells

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

A Brønsted-based deep eutectic solvent as a green catalyst for the sustainable one-pot synthesis of 1,2,4,5-tetrasubstituted imidazole derivatives: in vitro cytotoxicity and in silico binding studies on HepG2 cells

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading