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Pilot study assesses thimerosal hypersensitivity in patients using patch tests, indicating limited predictive value.
This pilot study was conducted to determine if prospective patch‐test screening could predict ocular tolerance to a thimerosal‐preserved chemical disinfection system. Thirty patients were patch tested for thimerosal hypersensitivity before beginning soft contact lens wear. Only one patient exhibited a positive prospective patch test and subsequently developed an ocular thimerosal hypersensitivity. Two other patients with negative patch tests developed thimerosal hypersensitivity reactions over the 1‐year study duration. Prospective patch testing for thimerosal hypersensitivity was neither clinically valuable nor sensitive in this particular sample.
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Adam Gordon (1988) studied this question.
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