High Fidelity Extended Duration Electroretinograms

Virtually all the major advances in vertebrate electroretinogram (ERG) analysis have been made with the use of animal models. Use of human subjects has been avoided largely because of the deleterious effects of many of the techniques used. In the present study, ERG's were recorded from two awake human subjects using direct coupled amplifiers. Pulse duration, wavelength, intensity, and adaptation state were systematically varied in order to produce the classical vertebrate ERG. By altering these stimulus parameters some seldom seen, previously unpublished, human ERG configurations were produced. These data provide a bridge between the human ERG and those previously obtained from other vertebrate preparations.