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This work aims to develop methods for site-specific investigation of biomolecular structures and dynamics using DNP-enhanced solid-state NMR.

March 21, 2026Open Access

Methods development for site-specific investigation of biomolecular structure and dynamics with DNP-enhanced solid-state NMR

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This work aims to develop methods for site-specific investigation of biomolecular structures and dynamics using DNP-enhanced solid-state NMR.
Developed matrix-free sample preparation techniques
Combined SCREAM-DNP with dipolar recoupling
Measured relaxation times under DNP conditions
Facilitated site-specific investigations of amyloid fibrils
Enabled analysis of ribonucleoprotein complexes
Improved methodologies for formulating active substances

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Methods development demonstrates enhanced investigation of biomolecular structures, suggesting improvements for structural biology.

Thomas Biedenbänder (2024) studied this question.

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