The theory demonstrates how the endothelium regulates corneal hydration, suggesting implications for eye health.
The details of our previously described theory of how the endothelium controls corneal hydration in the absence of the epithelium are provided. A central postulate is that the endothelium can produce across its limiting plasma membranes an osmotic gradient that reduces stromal swelling pressure so that it does not exceed intraocular pressure during thinning of a swollen cornea.
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Rehm et al. (1977) studied this question.
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