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Synapse
March 21, 2026Cell Reports0 citationsOpen Access

GIP receptor agonism suppresses inflammation-induced aversion and food intake via distinct circuits

HPHaley S. ProvinceNorthwestern UniversityNHNikolas W. HayesNorthwestern UniversityNLNelson LeongBrigham and Women's Hospital

Key Points

  • The aim is to explore how GIP receptor agonism affects food intake and aversion during inflammation.
  • Utilized experimental models to induce inflammation.
  • Administered GIP receptor agonists.
  • Measured changes in food intake and aversion behaviors.
  • GIP receptor activation significantly reduced aversion behaviors.
  • There was a notable decrease in food intake following inflammation.
  • Distinct neural circuits mediated the effects of GIP receptor agonism.

Abstract

GIP receptor agonism suppresses inflammation

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Cite This Study

Province et al. (2026) studied this question.

synapsesocial.com/papers/69be371c6e48c4981c67672bhttps://doi.org/10.1016/j.celrep.2026.117116
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