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March 21, 2026Wilderness and Environmental Medicine

Comparative Analysis of Pharmaceutical Content Following Spaceflight and Vacuum Exposure During Commercial Extravehicular Activity

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Authors

HBHayley BrawleyJRJohn F. ReichardKSKhaled Shennara

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Overview

Analyzing drug stability following spaceflight in a commercial space mission indicates no significant degradation.

Key Points

  • The research aims to evaluate the stability and degradation of pharmaceuticals after exposure to vacuum conditions in space.
  • Compared 19 medications from a spaceflight to matched terrestrial controls.
  • Utilized ultra-performance liquid chromatography mass spectrometry for analysis.
  • Measured active pharmaceutical ingredient differences between space and ground samples.
  • 17 of 19 medications had less than 5% mean difference in active ingredient between groups.
  • 7 medications showed significant differences, yet most remained within 5% of the expected content.
  • 10 ground controls and 11 spaceflight medications fell outside the narrow acceptable dosage range.

Cite This Study

Brawley et al. (2026) studied this question.

synapsesocial.com/papers/69be371c6e48c4981c6767d0https://doi.org/10.1177/10806032261426910
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Volumetric Absorptive Microsampling During Spaceflight for Analysis of Acetaminophen Pharmacokinetics in Whole Blood2026
  2. 2A framework for assessing the safety of degraded pharmaceuticals for long-duration space missions - Part 1: framework development2026
  3. 3The database of peptide medications for human deep-space missions demonstrates the potential for on-demand “Astropharmacy”2026 · 2 citations
  4. 4Expiration analysis of the International Space Station formulary for exploration mission planning2024 · 21 citations
  5. 5A framework for assessing the safety of degraded pharmaceuticals for long-duration space missions - Part 2: framework application in four case studies2026