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April 11, 2026Critical Reviews in Toxicology

A framework for assessing the safety of degraded pharmaceuticals for long-duration space missions - Part 1: framework development

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Authors

AMAndrey MassarskyVEVeneese J. B. EvansEFErnest S. Fung

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Overview

Framework assesses health risks associated with degraded medications in astronauts during space missions, indicating the need for safety protocols.

Key Points

  • This research aims to develop a framework for evaluating the safety of degraded pharmaceuticals for long-duration space missions.
  • Developed a five-step risk assessment framework.
  • Defined use scenarios for drugs in space missions.
  • Identified active pharmaceutical ingredient (API) degradants and their hazards.
  • Assessed the dose and risk of degradants based on existing data.
  • Utilized hazard databases and prediction tools for analysis.
  • Proposed framework highlights health effects of high concern, including acute toxicity and mutagenicity.
  • Risk characterization aligns with established health-based exposure limits.
  • Identified specific drugs for further analysis: azithromycin, diclofenac, gabapentin, and contraceptives.

Cite This Study

Massarsky et al. (2026) studied this question.

synapsesocial.com/papers/69d9e57078050d08c1b759a2https://doi.org/10.1080/10408444.2025.2533943
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