Case report reveals isolated alkaline phosphatase elevation in drug-induced liver injury, suggesting unusual presentation for clinicians.
In cholestatic drug-induced liver injury, serum liver function tests typically demonstrate concurrent elevations in alkaline phosphatase and γ-glutamyltransferase, with or without increases in alanine aminotransferase, aspartate aminotransferase, and total bilirubin. Isolated elevation of alkaline phosphatase is rare. Herein, we report a case of drug-induced liver injury characterized by isolated alkaline phosphatase elevation for clinicians. Following treatment with ursodeoxycholic acid, the patient achieved complete recovery. Clinicians should recognize that drug-induced liver injury may also present as an isolated elevation of alkaline phosphatase.
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Liu et al. (2026) studied this question.
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