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March 21, 2026Archiv der Pharmazie

AXL and c‐Met Dual‐Targeting in Non‐Small Cell Lung Cancer: A Review of Small‐Molecule Inhibitors and Their Structure–Activity Relationships

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Authors

HDHaifeng DongJiangxi Science and Technology Normal UniversityMYMing YuNantong UniversityYHYanyun HongXi'an University of Science and Technology

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Implication

This review examines the dual-targeting of AXL and c-Met in non-small cell lung cancer, suggesting therapeutic promise for small-molecule inhibitors.

Key Points

  • The aim is to explore the role of AXL and c-Met in non-small cell lung cancer and the effectiveness of targeting both with small-molecule inhibitors.
  • Reviewed literature on AXL and c-Met in NSCLC
  • Analyzed small-molecule inhibitors and their mechanisms
  • Summarized findings from clinical trials
  • AXL and c-Met are key oncogenic factors in NSCLC
  • Co-targeting shows substantial anti-tumor effects
  • Inhibition enhances treatment by addressing drug resistance and metastatic behavior

Cite This Study

Dong et al. (2026) studied this question.

synapsesocial.com/papers/69be37626e48c4981c676fc9https://doi.org/10.1002/ardp.70211
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Also Consider

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  1. 1Functional Expression and Mutations of c-Met and Its Therapeutic Inhibition with SU11274 and Small Interfering RNA in Non–Small Cell Lung Cancer2005 · 583 citations
  2. 2AURKB as a target in non-small cell lung cancer with acquired resistance to anti-EGFR therapy2019 · 151 citations
  3. 3Targeting MET in NSCLC: An Ever-Expanding Territory2024 · 29 citations
  4. 4A phase 2, open-label, multi-center study of amuvatinib in combination with platinum etoposide chemotherapy in platinum-refractory small cell lung cancer patients2017 · 19 citations
  5. 5c‐Met activation in lung adenocarcinoma tissues: An immunohistochemical analysis2007 · 145 citations