PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
Synapse
⌘+K
Synapse
March 21, 2026Clinical Kidney JournalOpen Access

Associations of plasma concentrations of heavy metals and trace elements with estimated glomerular filtration rate and chronic kidney disease: a population-based study

View Full Paper
Ask AI
Bookmark
Share

Authors

SXSisi XieATAurélien ThomasBPBelén Ponte

Discussion

Loading...

Member takes

Overview

Population-based study finds connections between heavy metals and kidney health measures, indicating health implications.

Key Points

  • This research investigates how plasma levels of heavy metals and trace elements relate to kidney function in adults.
  • Included adult participants from the SKIPOGH cohort (2008–2013)
  • Used multivariable linear and logistic regression for associations
  • Employed LASSO and weighted quantile sum regression to analyze mixture effects
  • Conducted multiple sensitivity analyses for robustness
  • Higher levels of tin, antimony, and iodine were linked with lower eGFR but did not remain significant after adjustment
  • Lower eGFR was observed in upper quartiles of zinc and thallium exposures
  • Molybdenum levels remained significantly linked to higher odds of CKD after adjustment
  • Iodine showed exploratory significance, with arsenic indicating a non-linear relationship with eGFR

Cite This Study

Xie et al. (2026) studied this question.

synapsesocial.com/papers/69be38216e48c4981c6785f6https://doi.org/10.1093/ckj/sfaf383
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1New Creatinine- and Cystatin C–Based Equations to Estimate GFR without Race2021 · 4,481 citations
  2. 2Association between urinary heavy metal/trace element concentrations and kidney function: a prospective study2024 · 19 citations
  3. 3Tributyltin chloride induces renal dysfunction by inflammation and oxidative stress in female rats2016 · 44 citations
  4. 4The crosstalk between copper-induced oxidative stress and cuproptosis: a novel potential anticancer paradigm2024 · 183 citations
  5. 5Zinc-Excess Intake Causes the Deterioration of Renal Function Accompanied by an Elevation in Systemic Blood Pressure Primarily Through Superoxide Radical-Induced Oxidative Stress2014 · 40 citations