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May 14, 2026Open Access

Associations of plasma concentrations of heavy metals and trace elements with estimated glomerular filtration rate and chronic kidney disease: a population-based study.

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Authors

SXSisi XieATAurélien ThomasBPBelén Ponte

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Overview

Population-based study investigates heavy metals' effects on kidney health, highlighting potential risks for chronic kidney disease.

Key Points

  • This study aims to explore how plasma levels of heavy metals and trace elements relate to kidney function and chronic kidney disease (CKD).
  • Population-based cohort from the Swiss Kidney Project on Genes in Hypertension (2008-2013) with 988 adults
  • Used multivariable linear and logistic regression to assess associations with estimated glomerular filtration rate (eGFR) and CKD
  • Employed weighted quantile sum regression to evaluate mixture effects of multiple elements.
  • Of 988 participants, 72 had chronic kidney disease (7.3%)
  • Molybdenum was significantly associated with higher odds of CKD after correction; higher zinc and thallium linked to lower eGFR in quartile analysis
  • No individual element remained significant for eGFR, indicating exploratory findings regarding iodine.

Cite This Study

Xie et al. (2026) studied this question.

synapsesocial.com/papers/6a05677ca550a87e60a1f814https://doi.org/10.48620/97647
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