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May 2, 2026

Associations of 24-h urinary excretion of heavy metals and trace elements with estimated glomerular filtration rate and chronic kidney disease.

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SXSisi XieATAurélien ThomasBPBelén Ponte

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Overview

Cross-sectional analysis assesses urinary heavy metal and trace element excretion impacts on kidney function, highlighting potential risks for chronic kidney disease.

Key Points

  • The aim was to investigate the associations between urinary excretion of heavy metals and trace elements with kidney function and chronic kidney disease.
  • Used cross-sectional data from the SKIPOGH cohort (2008-2013) involving 923 participants.
  • Evaluated associations using multivariable regression, nonlinear modeling, and fractional excretion analyses.
  • Assessed estimated glomerular filtration rate and chronic kidney disease presence among participants.
  • Positive associations identified between higher 24-h urinary excretion of vanadium, chromium, cobalt, and palladium with estimated glomerular filtration rate (eGFR).
  • Copper and zinc excretion was associated with increased odds of chronic kidney disease (CKD), while selenium, palladium, cadmium, and mercury showed inverse relationships.
  • Significant associations remained for vanadium, chromium, and palladium with eGFR, and for copper and mercury with CKD after correcting for multiple testing.

Cite This Study

Xie et al. (2026) studied this question.

synapsesocial.com/papers/69f594ca71405d493afffa37https://doi.org/10.1038/s41598-026-51034-8
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Associations of 24-h urinary excretion of heavy metals and trace elements with estimated glomerular filtration rate and chronic kidney disease.2026
  2. 2Associations of plasma concentrations of heavy metals and trace elements with estimated glomerular filtration rate and chronic kidney disease: a population-based study2026
  3. 3Associations of plasma concentrations of heavy metals and trace elements with estimated glomerular filtration rate and chronic kidney disease: a population-based study.2026
  4. 4Association between urinary concentrations of heavy metals and trace elements and renal function in Swiss adults: a cross-sectional study2024 · 1 citations
  5. 5Investigation of Combined Toxic Metals, PFAS, Volatile Organic Compounds, and Essential Elements in Chronic Kidney Disease2025 · 1 citations