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Observations reveal immediate corneal endothelial changes in unadapted individuals, indicating potential effects of contact lenses.
Changes in the appearance of the corneal endothelial mosaic have been observed within minutes after insertion of soft contact lenses in unadapted patients. The changes consist of increased separation between cells and circumscribed black zones (endothelial “blebs”) obscuring or displacing the mosaic.
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Zantos et al. (1977) studied this question.
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