What question did this study set out to answer?

This research aims to understand how person-level health factors influence the association between LGB identity, allostatic load, and cancer mortality.

March 21, 2026Cancer Causes & ControlOpen Access

Person-level health factors partially mediate the association between lesbian, gay, or bisexual (LGB) identity, allostatic load, and cancer mortality in NHANES

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This research aims to understand how person-level health factors influence the association between LGB identity, allostatic load, and cancer mortality.
Conducted a retrospective analysis of 12,470 participants from NHANES (2001–2010) linked to the National Death Index until 2019.
Utilized survey-weighted Cox regression to assess associations between LGB status, allostatic load, and cancer mortality.
Examined various person-level health factors as potential mediators including income, health access, and mental health visits.
LGB individuals with high allostatic load faced more than double the cancer mortality risk compared to heterosexuals.
Mediation analysis indicated that various health factors, particularly frequent healthcare visits and mental health provider access, partially influenced this relationship.
Notably, some mediators accounted for significant portions of the association, such as poor self-reported health (9.9%).

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Implication

Retrospective analysis reveals that health factors mediate cancer mortality risk in LGB individuals, suggesting implications for healthcare interventions.

Cite This Study

Moore et al. (2026) studied this question.

synapsesocial.com/papers/69be38a46e48c4981c679200 https://doi.org/10.1007/s10552-026-02145-0

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Implication

Retrospective analysis reveals that health factors mediate cancer mortality risk in LGB individuals, suggesting implications for healthcare interventions.

Person-level health factors partially mediate the association between lesbian, gay, or bisexual (LGB) identity, allostatic load, and cancer mortality in NHANES

Key Points

Discussion

Implication

Cite This Study

Person-level health factors partially mediate the association between lesbian, gay, or bisexual (LGB) identity, allostatic load, and cancer mortality in NHANES

Key Points

Discussion

Implication

Cite This Study

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