What question did this study set out to answer?

To assess the relationship between cumulative stress measured via allostatic load and the risk of cancer mortality, and to evaluate how this association differs across racial and ethnic groups.

July 31, 2022SSM - Population HealthOpen Access

Exploring racial disparities on the association between allostatic load and cancer mortality: A retrospective cohort analysis of NHANES, 1988 through 2019

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Authors

JMJustin X. MooreGeneral / Preventive / Lipids SASydney Elizabeth AndrzejakMercer (Czechia)MBMalcolm BevelAugusta University

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Implication

Retrospective cohort study reveals increased cancer mortality associated with high allostatic load in US adults, highlighting cumulative stress as a significant health risk factor.

Key Points

To assess the relationship between cumulative stress measured via allostatic load and the risk of cancer mortality, and to evaluate how this association differs across racial and ethnic groups.
Analyzed data from the National Health and Nutrition Examination Survey (NHANES, 1988–2010) linked with the National Death Index through December 31, 2019.
Used Fine & Gray Cox proportional hazards models adjusted for age, sociodemographics, and comorbidities to calculate sub-distribution hazard ratios (SHRs) comparing high versus low allostatic load.
High allostatic load was linked to a 14% higher risk of cancer death overall (adjusted SHR: 1.14, 95% CI: 1.04–1.26) and an 18% higher risk among Non-Hispanic White adults (SHR: 1.18, 95% CI: 1.03–1.34).
Among participants under 40 years of age, high allostatic load was associated with increased cancer mortality across the overall cohort (SHR: 1.80, 95% CI: 1.35–2.41), in Non-Hispanic White adults (SHR: 1.95, 95% CI: 1.22–3.12), and in Non-Hispanic Black adults (SHR: 2.06, 95% CI: 1.27–3.34), with a non-significant increase in Hispanic adults (SHR: 1.36, 95% CI: 0.70–2.62).

Cite This Study

Moore et al. (2022) studied this question.

synapsesocial.com/papers/6a1698539bb2c22b89b258ff https://doi.org/10.1016/j.ssmph.2022.101185

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Implication

Retrospective cohort study reveals increased cancer mortality associated with high allostatic load in US adults, highlighting cumulative stress as a significant health risk factor.

Exploring racial disparities on the association between allostatic load and cancer mortality: A retrospective cohort analysis of NHANES, 1988 through 2019

Discussion

Member takes

Implication

Key Points

Cite This Study

Exploring racial disparities on the association between allostatic load and cancer mortality: A retrospective cohort analysis of NHANES, 1988 through 2019

Discussion

Member takes

Implication

Key Points

Cite This Study

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