Key result
Each unit increase in allostatic load score linked to ~24% higher all-cause mortality risk.
Why the study?
Is a higher baseline allostatic load score associated with an increased risk of all-cause and cancer-specific mortality in Black and White adults aged 45 and older?
Population
29,701 Black and White participants aged 45 years and older in the REGARDS study
Comparison
Baseline allostatic load score evaluated per unit increase
Design
Prospective cohort study
Authors
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May stratify mortality risk in older adults; hypothesis-generating and should not yet change practice.
Cohort (n=29,701)
Yes
Is a higher baseline allostatic load score associated with an increased risk of all-cause and cancer-specific mortality in Black and White adults aged 45 and older?
Effect estimate: HR 1.24 (95% CI 1.22, 1.27)
Higher baseline allostatic load is associated with an increased risk of all-cause and cancer-specific mortality across both Black and White participants, suggesting that targeted interventions for high AL groups may be beneficial.
Akinyemiju et al. (2020) conducted a cohort in Allostatic load (n=29,701). Allostatic load score was evaluated on All-cause mortality (HR 1.24, 95% CI 1.22, 1.27). Every unit increase in baseline allostatic load score was associated with a 24% higher risk of all-cause mortality (HR 1.24; 95% CI 1.22-1.27) and a 7% higher risk of cancer-specific mortality.
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