What question did this study set out to answer?

The research aims to explore the anti-inflammatory effects of Lactiplantibacillus plantarum FS4722 and to optimize its lyophilization for enhanced viability.

March 21, 2026FoodsOpen Access

Anti-Inflammatory Effects of Lactiplantibacillus plantarum Strain FS4722 Through MAPK and NF-κB Signaling Pathways and Its Lyophilization Optimization

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Authors

BSBista SunitaSouth China University of Technology YLYuxing LiuFirst People's Hospital of Chongqing HZHanwei ZhengOcean University of China

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Implication

Authors investigate anti-inflammatory effects of Lactiplantibacillus plantarum FS4722, indicating improved probiotic viability and mechanisms in inflammation.

Key Points

The research aims to explore the anti-inflammatory effects of Lactiplantibacillus plantarum FS4722 and to optimize its lyophilization for enhanced viability.
Evaluated anti-inflammatory potential of Lactiplantibacillus plantarum FS4722 in LPS-stimulated RAW 264.7 macrophages
Assessed the efficacy of fermented supernatant, heat-inactivated suspension, and cell lysate
Optimized lyoprotectant formulation using component screening and response surface methodology
The fermented supernatant showed the strongest inhibition of inflammatory cytokines
Inhibition was mediated through MAPK and NF-κB signaling pathways
Lyophilization survival rate achieved was 82.32% with maintained cellular integrity
After 28 days at 4 °C, the strain retained 78.89% of its activity

Cite This Study

Sunita et al. (2026) studied this question.

synapsesocial.com/papers/69be38ca6e48c4981c679659 https://doi.org/10.3390/foods15061096

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Implication

Authors investigate anti-inflammatory effects of Lactiplantibacillus plantarum FS4722, indicating improved probiotic viability and mechanisms in inflammation.

Anti-Inflammatory Effects of Lactiplantibacillus plantarum Strain FS4722 Through MAPK and NF-κB Signaling Pathways and Its Lyophilization Optimization

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Member takes

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Key Points

Cite This Study

Anti-Inflammatory Effects of Lactiplantibacillus plantarum Strain FS4722 Through MAPK and NF-κB Signaling Pathways and Its Lyophilization Optimization

Discussion

Member takes

Implication

Key Points

Cite This Study

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