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March 21, 2026Open Access

COVID-19 Vaccine Effectiveness Among People Living With and Without HIV in South Carolina, USA: Protocol of a Population-Based Cohort Study

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Authors

XYXueying YangZPZhang, Jiajia, Ph.D.BOBankole Olatosi

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Overview

Cohort study compares COVID-19 breakthrough infection prevalence between HIV-positive and negative populations, indicating potential differences in vaccine effectiveness.

Key Points

  • This study aims to compare COVID-19 breakthrough infections between people living with HIV (PLWH) and those without, and assess the influence of HIV markers on vaccine effectiveness.
  • Merged electronic health records data from multiple cohorts in South Carolina.
  • Matched PLWH with non-PLWH using propensity score matching.
  • Conducted subgroup analyses of virally controlled and immunosuppressed PLWH.
  • Employed conditional logistic regression and generalized linear models for analysis.
  • Characterization of breakthrough COVID-19 prevalence and severity among PLWH and non-PLWH.
  • Assessment of the effect of HIV markers on vaccine effectiveness.
  • Findings will inform public health strategies regarding vaccination in HIV populations.

Cite This Study

Yang et al. (2024) studied this question.

synapsesocial.com/papers/69be38ca6e48c4981c679797https://doi.org/10.1136/bmjopen-2022-067095">https://doi.org/10.1136/bmjopen-2022-067095</a></p
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1COVID-19 Breakthrough Infections Among People With HIV: A Statewide Cohort Analysis2024 · 5 citations
  2. 2Clinical outcomes of coronavirus disease 2019 in people living with human immunodeficiency virus in South Korea: A nationwide population-based cohort study2024
  3. 3Clinical Outcomes of Coronavirus Disease 2019 in People Living With Human Immunodeficiency Virus in South Korea: A Nationwide Population‐Based Cohort Study2024 · 3 citations
  4. 4Cellular immune response of COVID-19 vaccines in people living with HIV: a systematic review and meta-analysis2026
  5. 5Risk of breakthrough infection and hospitalisation after COVID-19 primary vaccination by HIV status in four Italian regions during 20212024 · 5 citations