What does this research mean for the field?

COVID-19 vaccines elicit a significant cellular immune response in people living with HIV, but this response remains lower than in healthy controls and is significantly weaker for inactivated vaccines compared to mRNA or viral vector vaccines. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To assess and summarize cellular immune response rates following COVID-19 vaccination in people living with HIV (PLWH) compared to healthy controls.

August 29, 2026JAIDS Journal of Acquired Immune Deficiency Syndromes

Cellular immune response of COVID-19 vaccines in people living with HIV: a systematic review and meta-analysis

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Authors

SZShi ZouWuhan University YYYajun YanWuhan University JYJiuhong YeWuhan University

Discussion

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Implication

Systematic review and meta-analysis reveals lower cellular immunity after COVID-19 vaccination in people living with HIV, highlighting the benefit of booster doses.

Key Points

To assess and summarize cellular immune response rates following COVID-19 vaccination in people living with HIV (PLWH) compared to healthy controls.
Systematic search of PubMed, Embase, and Cochrane Central Register of Controlled Trials, including 18 eligible studies from 2,598 identified records.
Performed random-effects meta-analyses of response proportions measured by interferon-γ ELISPOT (n=4), ELISA (n=12), or flow cytometry (n=2).
Cellular immune response rates in PLWH were 63% (95% CI, 47–78%) after the second vaccine dose and increased to 88% (95% CI, 79–95%) after the third dose.
Pooled cellular response rates were comparable between mRNA (81%) and viral vector vaccines (83%), but were substantially lower for inactivated vaccines (49%).
PLWH exhibited significantly lower cellular immune responses compared to healthy controls (OR 0.65; 95% CI, 0.44–0.97).

Cite This Study

Zou et al. (2026) studied this question.

synapsesocial.com/papers/6a9299338e5d7d1fc0c110c3 https://doi.org/10.1097/qai.0000000000003961

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Implication

Systematic review and meta-analysis reveals lower cellular immunity after COVID-19 vaccination in people living with HIV, highlighting the benefit of booster doses.

Cellular immune response of COVID-19 vaccines in people living with HIV: a systematic review and meta-analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

Cellular immune response of COVID-19 vaccines in people living with HIV: a systematic review and meta-analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

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