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February 28, 2022npj VaccinesOpen Access

Humoral immune responses to COVID-19 vaccination in people living with HIV receiving suppressive antiretroviral therapy

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Authors

ZBZabrina L. BrummeFMFrancis MwimanziHLHope R. Lapointe

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Overview

Cohort study demonstrates robust antibody responses following two COVID-19 vaccine doses in adults with suppressed HIV, indicating standard two-dose regimens provide strong initial protection.

Key Points

  • To evaluate humoral immune responses to one and two doses of COVID-19 vaccines in people living with HIV receiving suppressive antiretroviral therapy compared to controls.
  • Prospective cohort assessing anti-SARS-CoV-2 spike RBD antibodies, ACE2 displacement, and viral neutralization in 100 adult PLWH on suppressive ART (median CD4+ 710 cells/mm³) and 152 controls.
  • Humoral markers were evaluated at one month following vaccine dose one, one month following dose two, and three months following dose two, adjusting for sociodemographic, health, and vaccine characteristics.
  • HIV infection was associated with significantly lower anti-RBD antibody concentrations and ACE2 displacement activity after a single vaccine dose following multivariable adjustment.
  • Following two vaccine doses, HIV infection was not significantly associated with the magnitude of any humoral response after multivariable adjustment.
  • Lower humoral responses after two doses were associated with older age, chronic comorbidities, and dual ChAdOx1 vaccination, with no significant correlation observed for recent or nadir CD4+ T-cell counts.

Cite This Study

Brumme et al. (2022) studied this question.

synapsesocial.com/papers/6a97d3a0827cb52371a67a97https://doi.org/10.1038/s41541-022-00452-6
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Also Consider

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