What type of study is this?

This is a Observational study (also classified as: Pre-Registered Trial).

August 21, 2025Journal of VirologyOpen Access

Inadequate immune response to inactivated COVID-19 vaccine among older people living with HIV: a prospective cohort study

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Authors

HZHangjie ZhangZhejiang Center for Disease Control and Prevention XDXuan DengChemical Synthesis Lab RDRongrong DaiJiangnan University

Discussion

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Implication

Prospective cohort study shows weakened immune response to inactivated COVID-19 vaccine in older PLWH, indicating urgent need for targeted strategies.

Key Points

Older people living with HIV exhibited a weaker immune response after vaccination with the inactivated COVID-19 vaccine, particularly those with low CD4 counts.
After two vaccine doses, the geometric mean titer of neutralizing antibodies in PLWH was significantly lower than healthy controls, at 46.9 vs 58.2.
The study employed a prospective cohort design, monitoring 400 participants across 4 regions in Zhejiang, China for vaccine safety and immunogenicity.
Findings stress the importance of developing strategies to enhance vaccine effectiveness among older PLWH with low immune responses.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68af56faad7bf08b1eadd437 https://doi.org/10.1128/jvi.00688-25

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Implication

Prospective cohort study shows weakened immune response to inactivated COVID-19 vaccine in older PLWH, indicating urgent need for targeted strategies.

Inadequate immune response to inactivated COVID-19 vaccine among older people living with HIV: a prospective cohort study

Discussion

Member takes

Implication

Key Points

Cite This Study

Inadequate immune response to inactivated COVID-19 vaccine among older people living with HIV: a prospective cohort study

Discussion

Member takes

Implication

Key Points

Cite This Study

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