Excessive Shear Rate, Not Shear Stress, Influences Cell Mechanical Damage in Small-Bore Needle Injections

G. W. Morgan; Jennifer Frattolin; Lamis Elsawah; Amelie Daudet; Daniel Watson; Nicola Contessi Negrini; Adam D. Celiz; JM Moore

doi:10.1115/1.4071455

March 20, 2026Journal of Biomechanical EngineeringOpen Access

Excessive Shear Rate, Not Shear Stress, Influences Cell Mechanical Damage in Small-Bore Needle Injections

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Key Points

To investigate the role of shear rate in causing mechanical damage to cells during small-bore needle injections.
Examined the impact of fluid mechanical parameters on cell survival during needle injections.
Analyzed the effects of varying shear rates and shear stresses in injection scenarios.
Findings indicate that shear rate is a more significant factor than shear stress in causing cell damage.
Implications for optimizing injection protocols to improve cell viability were identified.

Implication

Research highlights shear rate's role in cell mechanical damage during needle injection, suggesting better injection protocols to enhance viability.

Abstract

Knowledge that shear rate is the influential fluid mechanical parameter governing mechanical damage provides a rational basis for designing injection protocols (injectors and suspension fluid rheological properties) to maximize cell viability.

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Cite This Study

Morgan et al. (2026) studied this question.

synapsesocial.com/papers/69bf3924c7b3c90b18b43575 https://doi.org/10.1115/1.4071455

View Full Paper

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Excessive Shear Rate, Not Shear Stress, Influences Cell Mechanical Damage in Small-Bore Needle Injections

Key Points

Implication

Abstract

Discussion

Cite This Study

Excessive Shear Rate, Not Shear Stress, Influences Cell Mechanical Damage in Small-Bore Needle Injections

Key Points

Implication

Abstract

Discussion

Cite This Study

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