Key result
Fluid shear stress alters the function of vascular cells, leading to adaptive tissue responses and changes in structure, metabolism, and gene expression.
Population
Vascular cells (primarily endothelial cells and smooth muscle cells)
Design
Review
Authors
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Shear stress effects on endothelium may shape vascular device design; leaves open clinical translation pending targeted trials.
This review summarizes the molecular mechanisms by which fluid shear stress regulates gene expression and mechanotransduction in vascular endothelial and smooth muscle cells.
Papadaki et al. (1997) conducted a review in Cardiovascular system physiology. Fluid shear stress was evaluated. Fluid shear stress alters the function of vascular cells, leading to adaptive tissue responses and changes in structure, metabolism, and gene expression.