Design
Review
Key result
Fluid shear stress generated by blood flow profoundly influences endothelial phenotype by regulating flow-sensitive proteins and modulating gene expression.
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Fluid shear stress is a key biomechanical modulator of endothelial gene expression and phenotype, playing a mechanistic role in vascular remodeling and atherosclerosis.
Topper et al. (1999) conducted a review in Vascular remodeling and atherosclerosis. Fluid shear stress was evaluated on Endothelial phenotype and gene expression. Fluid shear stress generated by blood flow profoundly influences endothelial phenotype by regulating flow-sensitive proteins and modulating gene expression.
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