July 1, 1995The FASEB Journal

Hemodynamic forces are complex regulators of endothelial gene expression

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Population

Vascular endothelial cells (in vitro models)

Design

Review

Authors

NRNitzan ResnickBrigham and Women's Hospital MCMichael A. CimbroneBrigham and Women's Hospital

Discussion

Member takes

Implication

Biomechanical gene regulation may inform vascular pathophysiology; leaves open whether SSRE targeting alters clinical outcomes.

Structured PICO

Population

Vascular endothelial cells (in vitro models)

Intervention

Fluid mechanical forces (wall shear stress)

Outcome

Endothelial gene expression at the transcriptional levelsurrogate

Hemodynamic forces regulate vascular endothelial gene expression through specific genetic regulatory elements, integrating biomechanical stimuli in health and disease.

Cite This Study

Resnick et al. (1995) studied this question.

synapsesocial.com/papers/6a713e12f44fa9f079df075a https://doi.org/10.1096/fasebj.9.10.7615157

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Hemodynamic forces are complex regulators of endothelial gene expression

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Hemodynamic forces are complex regulators of endothelial gene expression

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider