Demonstrates effective oxidation of thiols to disulfides and thiosulfonates using molecular oxygen, suggesting a new method for controlled reactions.
A selective and controllable oxidation of thiols to disulfides or thiosulfonates has been developed using molecular oxygen, trifluoroacetic acid, and catalytic NaNO₃. Both aromatic and aliphatic thiols afford high yields. Sequential oxidation from thiols to disulfides and then to thiosulfonates was observed, with the second step governed by the acid concentration and substrate steric and electronic effects. Acid and oxygen cooperatively enable in situ generation and turnover of the active nitrosonium species.
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Shankar et al. (2026) studied this question.
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